Hope for the Future - Training New Clinicians and Advancing Research through the NUCDF Fellowship
The purpose of the NUCDF's Fellowship Grant is to improve the quality of care for urea cycle disorder-affected individuals by attracting promising new clinicians and researchers with interest in biochemical genetics to the field of urea cycle disorders. The Fellowship helps support postdoctoral fellows to specialize and focus on research, clinical treatment and coordination of multidisciplinary care of UCDs, while advancing the understanding and treatment of our disorders.
Sandesh Sreenath Nagamani, MBBS, MD
Recipient of 2011 NUCDF Fellowship Award
Dr. Nagamani is Assistant Professor, Department of Molecular and Human Genetics at Baylor College of Medicine in Houston, TX. He is board-certified in internal medicine and medical and clinical genetics. Dr. Nagamani received his M.D. from the University of Mysore in Karnataka, India, and completed internships and residencies at Gandhi Medical College in India, the Cleveland Clinic in OH, and at Baylor. Dr. Nagamani is a favorite of UCD families being followed in the Baylor Genetics Clinic and enrolled in the HPN-100 trial at the Baylor site. Dr. Nagamani will be continuing research on nitric oxide (NO) in ASA deficiency funded by NUCDF via our 2008 and 2009 NUCDF Fellowship Award recipients, Ayelet Arez, M.D., Ph.D., and Oleg Shchelochkov, M.D.
Dr. Nagamani says, “I have always been fascinated by the myriad pathways involved in disease pathogenesis and the modulation of one or more key pathways by therapeutic agents. The desire to be involved in understanding the mechanisms of disease and developing therapeutic interventions drove me towards a career in translational research. After graduating from Medical School and residency in Internal Medicine in India, I moved to the US to realize my ambition of becoming a physician scientist. After two years of clinical medicine residency, I enrolled in the research pathway track for a combined internal medicine and genetics fellowship at Baylor College of Medicine.”
“During my training in genetics at one of the largest metabolic centers in the US, I had the opportunity to evaluate and treat many patients with urea cycle disorders (UCDs). With appropriate treatment, there has been a significant impact on survival and this has have led to uncovering of the long-term complications such as liver dysfunction and hypertension in some UCDs like Argininosuccinic Aciduria (ASA). The mechanisms responsible for chronic consequences are not yet well characterized, precluding the development of therapeutic agents to prevent or treat these complications.”
“During my training in genetics, I was indeed fortunate to work in the clinic and the laboratory under the mentorship of Dr. Brendan Lee. Under his guidance, I have been involved in many clinical trials as well as understanding the link between urea cycle and nitric oxide production and its possible role in causation of long-term complications. I believe that the clinical and research experience gained from my training have equipped me with the aptitude to evaluate the role of nitric oxide in causation of hypertension in patients with ASA.”
“My long term goal is to continue integrating metabolic genetic and mouse genetics research to understand the contribution of NO dysregulation to human disease with a focus on UCDs. The ultimate goal would be to translate the findings back to patient care. The research support provided by NUCDF will be leveraged into obtaining a National Institutes of Health K-award that would allow my transition into an independent researcher.”
SUPPORT THE IMPACT OF THE NUCDF FELLOWSHIP AWARD
The NUCDF Fellowship Award is one way we pursue our mission to stimulate and support research, while at the same time training new clinicians to care for the growing population of those affected by urea cycle disorders. The research supported by the Fellowship has transformed the understanding of urea cycle disorders in just a few short years. NUCDF Fellows have begun clinical practice in underserved regions of the US and are caring for a new generation of children diagnosed with UCD, who would not otherwise have been diagnosed or had access to a UCD specialist.
The generosity of our donors supports this program. Your donation can help expand the program so that NUCDF can offer more than one fellowship each year, and multiply the impact. Thank you for your support and making an impact on the lives of those affected by urea cycle disorders.
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